Hi DRBT,
As you know I think very highly of SleepEZ and the Roma would certainly make a great quality/value choice and I would consider the materials it uses to be “safe enough” as long as you are comfortable with the CertiPUR certified polyfoam in the quilting.
There is more information about the pros and cons of different types of mattress protectors and some good sources for each of them in post #89 here that should be helpful.
The Sleep & Beyond mattress protector That SleepEZ sells uses natural cotton and natural wool and a waterproof membrane which I would also consider it to be “safe enough” even though it’s not organic.
Phoenix