Hi mfische2,
The choice between different types and blends of latex is more of a preference choice than anything else (although of course budget will play a role as well). There is more about the different types and blends of latex in post #6 here and there is also more about the pros and cons of synthetic rubber vs natural rubber in post #2 here and how the “feel” of Dunlop compares to Talalay in post #7 here.
Synthetic latex is also less dense than natural latex so a synthetic Dunlop latex mattress will have a lower compression modulus (how quickly a foam becomes firmer as you sink into it more deeply) so you will sink into it more deeply than you would with the same ILD of natural Dunlop. It will also be less elastic than natural Dunlop.
Both are durable materials and there would be no obvious weak links in terms of durability in a mattress that used either one of them.
There will be some slight foam softening or slight impressions with all foam materials (including latex) over time so the sleeping surface won’t generally remain “pancake flat” and any quilting materials like wool or polyfoam can also develop some slight softening (in the case of polyfoam) or impressions (in the case of wool) as well but if they are good quality materials (like latex) then the softening or impressions will be very slight and not to the degree that it will have any meaningful effect on comfort or support (unlike the type or degree of foam softening or impressions that goes with lower quality materials such as lower density polyfoam or memory foam that is used in most mainstream mattresses). It certainly isn’t something I would be concerned about with latex.
Phoenix