Hi hermanski,
There would be many “it depends” in the answer including the specifics of the mattress and the person. It would probably be fair to say that for “most” people there would be “some” difference both in terms of PPP (Posture and alignment, Pressure relief, and Personal preferences) and durability and for some or even many people there could be “significant” differences (more in terms of PPP and performance than durability if both mattresses are using good quality and durable materials) … but again it would depend on the specifics of the mattresses you were comparing and the person. There is more about the differences between a polyfoam/latex hybrid and an all latex mattress in post #2 here and in post #2 here.
Phoenix