Hi TAGG,
All latex regardless of type is a higher quality material but you can read more about the different types and how they compare in post #6 here. There is some more technical information about the differences between SBR (Styrene Butadiene or synthetic latex) and NR (Natural Rubber) in post #2 here.
Probably not a “significant” issue no but in combination with other risk factors it could increase the possibility of issues that come from lack of ventilation in between the mattress and the base. You can read more about this in post #10 here. I would also tend towards a slatted base over a wire grid base for an all latex mattress for similar reasons (see post #10 here) because of the additional risk of a latex layer on the bottom compressing into the gaps over time. This would not be a concern with a firm polyfoam bottom layer in a mattress.
Phoenix