Hi cviz,
Just in case you haven’t read it yet … the first place i would start your research is post #1 here which has the basic information, steps, and guidelines you will need to make the best possible choices.
If the mattress uses materials that are suitable for use on an adjustable bed then in most cases no or at least not significantly. All mechanical forces such as compression or bending will have some effect on the materials over time but better quality materials or foams are very durable and can easily withstand the extra bending with little negative effect on durability. I would also make sure you ask the manufacturer or retailer of a mattress about using it on an adjustable bed to confirm it would be suitable (there are a few exceptions or foam types which may not do as well on an adjustable bed) and to make sure it meets the criteria of the warranty.
The thickness of the mattress is not nearly as important as what is in the mattress. Thick mattresses that use lower quality materials (which is the “norm” with many of the major manufacturers) are less durable than much thinner mattresses that use higher quality materials. Mattress thickness in other words is more of a marketing poly if the thickness comes from lower quality materials. There are some legitimate benefits in some cases for a thicker mattress which uses high quality materials though which you can read about in post #14 here.
A mattress softens and breaks down from the top down so the top layers of a mattress are the “weak link” of most mattresses in terms of durability and the heavier you are the more important the quality of the top layers are. For someone who was lighter the top 3" or so may be the most important while for someone who was heavier then the top 6" or so may be more important because heavier weights will sink into the mattress layers more deeply. The extra layer of latex is a “transition” layer which acts partly for comfort and partly for support and in addition to the performance benefits … latex is more durable than polyfoam. You can read a little more about some of the benefits of all latex vs a latex polyfoam hybrid in post #2 here. In the case of the Aloe Alexis, the top two layers (6") would be latex so this would be beneficial in terms of durability for higher weights than a mattress where only the top layer used latex such as in the Bamboo Bliss (which uses high quality materials but only has 3" of latex so if you were heavier then you would “go through” the top 3" more and the durability of the layers below this become more important).
I guess it would depend on the relative size of the bank but IMO, in most cases absolutely yes 
The other benefit of a mattress which has exchangeable layer is if you do lose weight and your needs and preferences change as a result then you can just replace a layer for a different firmness/softness level instead of the entire mattress.
Phoenix